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Complement activation, lipid metabolism, and mitochondrial injury: Converging pathways in age-related macular degeneration

1 Oct 2020

Abstract excerpt

The retinal pigment epithelium (RPE) is the primary site of injury in non-neovascular age-related macular degeneration or dry AMD. Polymorphisms in genes that regulate complement activation and cholesterol metabolism are strongly associated with AMD, but the biology underlying disease-associated variants is not well understood. Here, we highlight recent studies that have used molecular, biochemical, and live-cell...

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PMID: 33162377
DOI: 10.1016/j.redox.2020.101781

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