Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.

doi:10.1073/pnas.1121309109

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Article

Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.

Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2012

Shaw Peter X, Zhang Li, Zhang Ming, Du Hongjun, Zhao Ling, Lee Clara, Grob Seanna, Lim Siok Lam, Hughes Guy, Lee Janet, Bedell Matthew, Nelson Mark H, Lu Fang, Krupa Martin, Luo Jing, Ouyang Hong, Tu Zhidan, Su Zhiguang, Zhu Jin, Wei Xinran, Feng Zishan, Duan Yaou, Yang Zhenglin, Ferreyra Henry, Bartsch Dirk-Uwe, Kozak Igor, Zhang Liangfang, Lin Feng, Sun Hui, Feng Hong, Zhang Kang

Abstract excerpt

The rs1061170T/C variant encoding the Y402H change in complement factor H (CFH) has been identified by genome-wide association studies as being significantly associated with age-related macular degeneration (AMD). However, the precise mechanism by which this CFH variant impacts the risk of AMD remains largely unknown. Oxidative stress plays an important role in many aging diseases, including cardiovascular...

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PMID: 22875704
DOI: 10.1073/pnas.1121309109
PMCID: PMC3427125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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