Article
Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo.
PloS one - 1 Jan 2016
Zhang Michael, Hutter Gregor, Kahn Suzana A, Azad Tej D, Gholamin Sharareh, Xu Chelsea Y, Liu Jie, Achrol Achal S, Richard Chase, Sommerkamp Pia, Schoen Matthew Kenneth, McCracken Melissa N, Majeti Ravi, Weissman Irving, Mitra Siddhartha S, Cheshier Samuel H
Abstract excerpt
Tumor-associated macrophages (TAMs) represent an important cellular subset within the glioblastoma (WHO grade IV) microenvironment and are a potential therapeutic target. TAMs display a continuum of different polarization states between antitumorigenic M1 and protumorigenic M2 phenotypes, with a lower M1/M2 ratio correlating with worse prognosis. Here, we investigated the effect of macrophage polarization on...
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