Article
Important denominator between autoimmune comorbidities: a review of class II HLA, autoimmune disease, and the gut.
Frontiers in immunology - 1 Jan 2023
Berryman Meghan A, Ilonen Jorma, Triplett Eric W, Ludvigsson Johnny
Abstract excerpt
Human leukocyte antigen (HLA) genes are associated with more diseases than any other region of the genome. Highly polymorphic HLA genes produce variable haplotypes that are specifically correlated with pathogenically different autoimmunities. Despite differing etiologies, however, many autoimmune disorders share the same risk-associated HLA haplotypes often resulting in comorbidity. This shared risk remains an...
Topics
- Humans
- HLA-DQ Antigens
- Dysbiosis
- Genetic Predisposition to Disease
- Autoimmune Diseases
- HLA Antigens
- Comorbidity