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Article

The immunogenetic architecture of autoimmune disease.

Cold Spring Harbor perspectives in biology - 1 Mar 2012

Goris An, Liston Adrian

Abstract excerpt

The development of most autoimmune diseases includes a strong heritable component. This genetic contribution to disease ranges from simple Mendelian inheritance of causative alleles to the complex interactions of multiple weak loci influencing risk. The genetic variants responsible for disease are being discovered through a range of strategies from linkage studies to genome-wide association studies. Despite the...

Topics

Autoimmune Diseases
Genetic Predisposition to Disease
Genetic Variation
HLA Antigens
Humans
Models, Genetic

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22383754
DOI: 10.1101/cshperspect.a007260
PMCID: PMC3282406

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