Article

The lupus susceptibility allele <i>DRB1*03:01</i> encodes a disease-driving epitope

2022-05-31

Abstract excerpt

<h4>ABSTRACT</h4> The HLA-DRB1*03:01 allele is a major genetic risk factor in systemic lupus erythematosus (SLE), but the mechanistic basis of the association is unclear. Here we show that in the presence of interferon gamma (IFN-γ), a short DRB1*03:01 -encoded allelic epitope activates a characteristic lupus transcriptome in mouse and human macrophages. It also triggers a cascade of SLE-associated cellular abe...

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Literature Corpus work: 242e1772-5a91-5840-aa5e-b4384f9080e2
DOI: 10.1101/2022.05.31.494172

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