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Blimp-1 Contributes to the Development and Function of Regulatory B Cells

14 Aug 2019

Abstract excerpt

Regulatory B cells (Bregs) are a B cell subset that plays a suppressive role in immune responses. The CD19+CD1dhiCD5+ Bregs that can execute regulatory functions via secreting IL-10 are defined as B10 cells. Bregs suppress autoimmune and inflammatory diseases, whereas they exacerbate infectious diseases caused by bacteria, viruses, or parasites. Notably, the molecular mechanisms regulating the development and...

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PMID: 31474988
DOI: 10.3389/fimmu.2019.01909

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