Article

Genetic analysis implicates<i>ERAP1</i>and HLA as risk factors for severe Puumala virus infection

2024-06-28

Abstract excerpt

Puumala virus (PUUV) infections can cause severe illnesses such as Hemorrhagic Fever with Renal Syndrome in humans. However, human genetic risk factors contributing to disease severity are still poorly understood. Our goal was to elucidate genetic factors contributing to PUUV infections and understand the biological mechanisms underlying individual vulnerability to the disease. Leveraging data from the FinnGen stu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 232d61b0-44d4-5692-b827-68b4821a171c
DOI: 10.1101/2024.06.28.24309633

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis implicates<i>ERAP1</i>and HLA as risk factors for severe Puumala virus infectionDOI 10.1101/2024.06.28.24309633Read

Genetic analysis implicates ERAP1 and HLA as risk factors for severe Puumala virus infection.Semantic proximity Read

Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa feverSemantic proximity Read

A genome-wide association study in a large community-based cohort identifies multiple loci associated with susceptibility to bacterial and viral infections.Semantic proximity Read

The landscape of host genetic factors involved in immune response to common viral infectionsSemantic proximity Read

Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection.Semantic proximity Read

Variation in<i>ERAP2</i>has opposing effects on severe respiratory infection and autoimmune diseaseSemantic proximity Read

Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.Semantic proximity Read

Heterozygous TLR3 Mutation in Patients with Hantavirus Encephalitis.Semantic proximity Read

The Search of Association of HLA Class I and Class II Alleles with COVID-19 Mortality in the Russian Cohort.Semantic proximity Read

The landscape of host genetic factors involved in immune response to common viral infections.Semantic proximity Read

THE SEARCH FOR AN ASSOCIATION OF HLA ALLELES AND COVID-19 RELATED MORTALITY IN THE RUSSIAN POPULATIONSemantic proximity Read

Structural and biochemical insights into the association between ERAP1 polymorphism and autoimmune diseases.Semantic proximity Read