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Genetic analysis implicates ERAP1 and HLA as risk factors for severe Puumala virus infection.

Human molecular genetics - 23 Jan 2025

Haapaniemi Hele, Strausz Satu, Tervi Anniina, Jones Samuel E, Kanerva Mari, Abner Erik, Fors Connolly Anne-Marie, Ollila Hanna M

Abstract excerpt

Puumala virus (PUUV) infections can cause severe illnesses such as Hemorrhagic Fever with Renal Syndrome in humans. However, human genetic risk factors contributing to disease severity are still poorly understood. Our goal was to elucidate genetic factors contributing to PUUV infections and understand the biological mechanisms underlying individual vulnerability to PUUV infections. Leveraging data from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39533856
DOI: 10.1093/hmg/ddae158
PMCID: PMC11756300

Genes

ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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