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Article

Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection.

Thrombosis research - 1 May 2012

Laine Outi, Joutsi-Korhonen Lotta, Mäkelä Satu, Mikkelsson Jussi, Pessi Tanja, Tuomisto Sari, Huhtala Heini, Libraty Daniel, Vaheri Antti, Karhunen Pekka, Mustonen Jukka

Abstract excerpt

INTRODUCTION: Puumala virus (PUUV) infection is a viral hemorrhagic fever with renal syndrome (HFRS) characterized by thrombocytopenia and acute impairment of renal function. We aimed to assess whether genetic polymorphisms of platelet antigens together with those of von Willebrand factor (VWF) and plasminogen activator inhibitor (PAI-1) correlate with disease severity. Patients and methods 172 consecutive...

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Identifiers

PMID: 22133274
DOI: 10.1016/j.thromres.2011.11.007
PMCID: PMC3879723

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VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection.PMID 22133274Read ↗

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