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Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever

7 Feb 2024

Abstract excerpt

Infection with Lassa virus (LASV) can cause Lassa fever, a haemorrhagic illness with an estimated fatality rate of 29.7%, but causes no or mild symptoms in many individuals. Here, to investigate whether human genetic variation underlies the heterogeneity of LASV infection, we carried out genome-wide association studies (GWAS) as well as seroprevalence surveys, human leukocyte antigen typing and high-throughput...

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PMID: 38326571
DOI: 10.1038/s41564-023-01589-3

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