Article
Heterozygous TLR3 Mutation in Patients with Hantavirus Encephalitis.
Journal of clinical immunology - 1 Nov 2020
Partanen Terhi, Chen Jie, Lehtonen Johanna, Kuismin Outi, Rusanen Harri, Vapalahti Olli, Vaheri Antti, Anttila Veli-Jukka, Bode Michaela, Hautala Nina, Vuorinen Tytti, Glumoff Virpi, Kraatari Minna, Åström Pirjo, Saarela Janna, Kauma Heikki, Lorenzo Lazaro, Casanova Jean-Laurent, Zhang Shen-Ying, Seppänen Mikko, Hautala Timo
Abstract excerpt
Puumala hantavirus (PUUV) hemorrhagic fever with renal syndrome (HFRS) is common in Northern Europe; this infection is usually self-limited and severe complications are uncommon. PUUV and other hantaviruses, however, can rarely cause encephalitis. The pathogenesis of these rare and severe events is unknown. In this study, we explored the possibility that genetic defects in innate anti-viral immunity, as analogous...
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