Article

Divergent Loop Architecture Shapes Pocket 2 Variation in Shark Legumains

2026-06-06

Abstract excerpt

Legumain (AEP) is a cysteine protease with a highly conserved catalytic core but variable surface features whose evolutionary and structural diversity remain incompletely understood. To investigate how these features differ across vertebrates, we compared human legumain with six shark orthologs using sequence alignment, AlphaFold based structural modeling, pocket detection, and qualitative docking. All shark seque...

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Literature Corpus work: 230c676b-7b50-5028-aab3-90f345d3518a
DOI: 10.64898/2026.06.04.730232

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