Article
Foci of amino acid residue conservation in the 3D structures of the Kunitz BPTI proteinase inhibitors: how do variants from snake venom differ?
Protein engineering - 1 Feb 1997
Cardle L, Dufton M J
Abstract excerpt
The Kunitz BPTI proteinase inhibitor family is divisible into subgroups based on source and bioactivity. Variants from snake venoms are of special interest because some show only weak inhibitory activity against the common proteinases while others are neurotoxic. We analysed the sequences for eac...
Topics
- Amino Acid Sequence
- Animals
- Aprotinin
- Binding Sites
- Bungarotoxins
- Cattle
- Conserved Sequence
- Elapid Venoms
- Evolution, Molecular
- Genetic Variation
- Models, Molecular
- Molecular Structure
- Protein Conformation
- Protein Engineering
- Snake Venoms