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Article

Trench-shaped Binding Sites Promote Multiple Classes of Interactions between Collagen and the Adherence Receptors, α1β1 Integrin and Staphylococcus aureus Cna MSCRAMM

1 Aug 1999

Abstract excerpt

Most mammalian cells and some pathogenic bacteria are capable of adhering to collagenous substrates in processes mediated by specific cell surface adherence molecules. Crystal structures of collagen-binding regions of the human integrin alpha(2)beta(1) and a Staphylococcus aureus adhesin reveal a "trench" on the surface of both of these proteins. This trench can accommodate a collagen triple-helical structure and...

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PMID: 10455165
DOI: 10.1074/jbc.274.35.24906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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