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From Generalist to Specialist: Evolution of PS2 α-integrins and Implications for Drug Targeting

2026-05-01

Abstract excerpt

Integrins are heterodimeric transmembrane receptors that mediate cell–cell and cell– extracellular matrix interactions and play essential roles in development and disease. Within the PS2 α-integrin subfamily, four paralogs (αIIb, α5, α8, and αV) share a conserved RGD-binding motif yet exhibit diverse functional specializations. Integrins have been widely targeted therapeutically for various clinical conditions, th...

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Literature Corpus work
f1539068-5198-509b-9f0b-150ccf15a2ee
DOI
10.64898/2026.04.29.721650
Open publication

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