Article

Computational protein engineering of a multivalent human metapneumovirus immunogen using the self-assembling RSV M2-1 tetrameric scaffold

2026-08-19

Abstract excerpt

<title>Abstract</title> <p>Developing highly immunogenic subunit vaccines against human metapneumovirus (HMPV) remains a persistent challenge because isolated epitopes are inherently unstable and effective multivalent presentation strategies are lacking. In this study, we present an advanced computational protein engineering framework that uses the stable, self-assembling tetrameric architecture of the Respirator...

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Literature Corpus work: 230bad2d-c2c4-55d3-b562-6c174fc23c98
DOI: 10.21203/rs.3.rs-10152885/v1

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