Article

Single-component multilayered self-assembling protein nanoparticles displaying extracellular domains of matrix protein 2 as a pan-influenza A vaccine

2023-06-02

Abstract excerpt

<h4>ABSTRACT</h4> The development of a cross-protective pan-influenza A vaccine remains a significant challenge. In this study, we designed and evaluated single-component self-assembling protein nanoparticles (SApNPs) presenting the conserved extracellular domain of matrix protein 2 (M2e) as vaccine candidates against influenza A viruses. The SApNP-based vaccine strategy was first validated for human M2e (hM2e) a...

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Literature Corpus work: f4856394-d6fd-57dc-a70d-96607b713f1b
DOI: 10.1101/2023.06.02.543464

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