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Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2021

Stewart-Jones Guillaume B E, Gorman Jason, Ou Li, Zhang Baoshan, Joyce M Gordon, Yang Lijuan, Cheng Cheng, Chuang Gwo-Yu, Foulds Kathryn E, Kong Wing-Pui, Olia Adam S, Sastry Mallika, Shen Chen-Hsiang, Todd John-Paul, Tsybovsky Yaroslav, Verardi Raffaello, Yang Yongping, Collins Peter L, Corti Davide, Lanzavecchia Antonio, Scorpio Diana G, Mascola John R, Buchholz Ursula J, Kwong Peter D

Abstract excerpt

Human metapneumovirus (HMPV) is a major cause of respiratory disease worldwide, particularly among children and the elderly. Although there is no licensed HMPV vaccine, promising candidates have been identified for related pneumoviruses based on the structure-based stabilization of the fusion (F) glycoprotein trimer, with prefusion-stabilized F glycoprotein trimers eliciting significantly higher neutralizing...

Topics

Animals
Antibodies, Neutralizing
Antibodies, Viral
Disulfides
Epitopes
Glycoproteins
Humans
Immunization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macaca

Metapneumovirus

Mice

Mutation

Promoter Regions, Genetic

Source

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Identifiers

PMID: 34551978
DOI: 10.1073/pnas.2106196118
PMCID: PMC8488613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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