Article

Divergence of the individual repeats in the leucine-rich repeat domains of human Toll-like receptors explain their diversity and functional adaptations

2024-10-01

Abstract excerpt

Toll-like receptors (TLRs) are best known pattern recognition receptors of innate immunity, detecting a broad range of pathogen-associated molecular patterns (PAMPs), and endogenous danger associated molecular patterns (DAMPs), initiating inflammatory and antimicrobial responses. TLRs contain two specialized domains, a signaling domain (TIR), and a receptor domain composed of tandem repeats of short 20-30 amino ac...

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Literature Corpus work: 23093ae2-c6c8-54f8-8222-77743501622f
DOI: 10.1101/2024.09.30.615863

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