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Article

Phospholipase D functional ablation has a protective effect in an Alzheimer's disease Caenorhabditis elegans model.

Scientific reports - 23 Feb 2018

Bravo Francisca Vaz, Da Silva Jorge, Chan Robin Barry, Di Paolo Gilbert, Teixeira-Castro Andreia, Oliveira Tiago Gil

Abstract excerpt

Phospholipase D (PLD) is a key player in the modulation of multiple aspects of cell physiology and has been proposed as a therapeutic target for Alzheimer's disease (AD). Here, we characterize a PLD mutant, pld-1, using the Caenorhabditis elegans animal model. We show that pld-1 animals present decreased phosphatidic acid levels, that PLD is the only source of total PLD activity and that pld-1 animals are more...

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Identifiers

PMID: 29476137
DOI: 10.1038/s41598-018-21918-5
PMCID: PMC5824944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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