Article

α-lipoic acid has the potential to normalize copper metabolism, which is dysregulated in Alzheimer’s disease

2021-03-16

Abstract excerpt

Alzheimer’s disease (AD) is an age-dependent progressive neurodegenerative disorder and the most common cause of dementia. The treatment and prevention of AD present immense yet unmet needs. One of the hallmarks of AD is the formation of extracellular amyloid plaques in the brain, composed of amyloid-beta (Aβ) peptides. Multiple amyloid-targeting drug candidates have recently failed in clinical trials, which creat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23aefefe-04f8-5bc6-9419-2471743c2f0c
DOI: 10.1101/2021.03.15.435417

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

α-lipoic acid has the potential to normalize copper metabolism, which is dysregulated in Alzheimer’s diseaseDOI 10.1101/2021.03.15.435417Read

Low-copper diet as a preventive strategy for Alzheimer's disease.Semantic proximity Read

A Concise Review on Oxidative Stress-Mediated Ferroptosis and Cuproptosis in Alzheimer’s DiseaseSemantic proximity Read

Metallo-pathways to Alzheimer's disease: lessons from genetic disorders of copper trafficking.Semantic proximity Read

Behavioural effects and RNA-seq analysis of Aβ42 mediated toxicity in a Drosophila Alzheimer’s disease modelSemantic proximity Read

Using Drosophila amyloid toxicity models to study Alzheimer's diseaseSemantic proximity Read

Zinc transporters in Alzheimer’s diseaseSemantic proximity Read

Environmental and Dietary Exposure to Copper and Its Cellular Mechanisms Linking to Alzheimer’s DiseaseSemantic proximity Read

Suppression of the dihydrolipoamide dehydrogenase gene ( <i>dld-1</i> ) protects against the toxicity of human amyloid beta in <i>C. elegans</i> model of Alzheimer’s diseaseSemantic proximity Read

The Role of Copper in Alzheimer’s Disease Etiopathogenesis: An Updated Systematic ReviewSemantic proximity Read

Copper: From enigma to therapeutic target for neurological disorderSemantic proximity Read

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD.Semantic proximity Read

Copper and Zinc Homeostasis: Lessons from Drosophila melanogasterSemantic proximity Read