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Dichloroacetate improves animal survival, growth, neuromuscular activity, mitochondrial stress and physiology, and elevated lactate in <i>C. elegans pdha-1</i> and <i>dld-1</i> RNAi models of pyruvate dehydrogenase complex deficiency (PDCD)

2026-07-10

Abstract excerpt

<h4>ABSTRACT</h4> Pyruvate dehydrogenase complex (PDHc) deficiency (PDCD) is a primary mitochondrial disorder characterized by neurodevelopmental disability, altered intermediary metabolism and early mortality. Dichloroacetate (DCA), a pyruvate analogue, is a well-described PDHc activator that remains under clinical investigation for treatment of PDCD. Here, we studied the in vivo efficacy of a 5-point log conce...

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Literature Corpus work
21affbbf-4f5e-53ae-a25d-0d8c80444db0
DOI
10.64898/2026.07.08.737008
Open publication

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Dichloroacetate improves animal survival, growth, neuromuscular activity, mitochondrial stress and physiology, and elevated lactate in <i>C. elegans pdha-1</i> and <i>dld-1</i> RNAi models of pyruvate dehydrogenase complex deficiency (PDCD)DOI 10.64898/2026.07.08.737008
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