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Article

A metabolic signature for long life in the Caenorhabditis elegans Mit mutants.

Aging cell - 1 Feb 2013

Butler Jeffrey A, Mishur Robert J, Bhaskaran Shylesh, Rea Shane L

Abstract excerpt

Mit mutations that disrupt function of the mitochondrial electron transport chain can, inexplicably, prolong Caenorhabditis elegans lifespan. In this study we use a metabolomics approach to identify an ensemble of mitochondrial-derived α-ketoacids and α-hydroxyacids that are produced by long-lived Mit mutants but not by other long-lived mutants or by short-lived mitochondrial mutants. We show that accumulation of...

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Identifiers

PMID: 23173729
DOI: 10.1111/acel.12029
PMCID: PMC3552119

Genes

DLD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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