Article

Variants of <i>DNMT3A</i> cause transcript-specific DNA methylation patterns and affect hematopoietic differentiation

2018-05-09

Abstract excerpt

The de novo DNA methyltransferase 3A (DNMT3A) plays pivotal roles in hematopoietic differentiation. In this study, we followed the hypothesis that alternative splicing of DNMT3A has characteristic epigenetic and functional sequels. Specific DNMT3A transcripts were either downregulated or overexpressed in human hematopoietic stem and progenitor cells and this resulted in complementary and transcript-specific DNA...

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Literature Corpus work: 22ee1fff-6802-590b-bfe7-8e638d518fcb
DOI: 10.1101/318188

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