Article
Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia.
Leukemia - 1 Aug 2014
Celton M, Forest A, Gosse G, Lemieux S, Hebert J, Sauvageau G, Wilhelm B T
Abstract excerpt
The GATA2 gene encodes a zinc-finger transcription factor that acts as a master regulator of normal hematopoiesis. Mutations in GATA2 have been implicated in the development of myelodysplastic syndrome and acute myeloid leukemia (AML). Using RNA sequencing we now report that GATA2 is either mutated with a functional consequence, or expressed at low levels in the majority of normal karyotype AML (NK-AML). We also...
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