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Article

Molecular genetics and targeted therapy of WNT-related human diseases (Review).

International journal of molecular medicine - 1 Sept 2017

Katoh Masuko, Katoh Masaru

Abstract excerpt

Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the WNT/β-catenin and WNT/stabilization of proteins (STOP) signaling cascades to regulate cell fate and proliferation, whereas non-canonical WNT signaling through Frizzled or ROR receptors is transduced to the WNT/planar cell polarity (PCP), WNT/G protein-coupled receptor (GPCR) and WNT/receptor tyrosine kinase (RTK) signaling cascades...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28731148
DOI: 10.3892/ijmm.2017.3071
PMCID: PMC5547940

Genes

OMP
ROR1
RSPO3
APC
CTNNB1
DKK1
RNF43
RSPO2
SOST
ZNRF3
FZD10
FZD5
LRP5
PORCN
ROR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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