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Article

PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers

7 Aug 2019

Abstract excerpt

Pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) is aggressive and lethal. Although there is an urgent need for effective therapeutics in treating pancreatic cancer, none of the targeted therapies tested in clinical trials to date significantly improve its outcome. PORCN inhibitors show efficacy in preclinical models of Wnt-addicted cancers, including RNF43-mutant pancreatic cancers and have advanced to...

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PMID: 31391551
DOI: 10.1038/s41388-019-0908-1

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