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Article

Epithelial WNT secretion drives niche escape of developing gastric cancer.

Molecular cancer - 16 Dec 2025

Lee Jaehun, Kim Soomin, Oh Youngchul, Jahn Stephan R, Kim Jihoon, Kim Yeongjun, Schmäche Tim, Kim Sang-Min, Teriyapirom Isaree, Groß Thomas, Kwon Ohbin, Kim Jungmin, Kim Somi, Ada Anne-Marlen, Català-Bordes Andrea, Cho Youngwon, Kim Jinho, Andersson-Rolf Amanda, Merker Sebastian R, Lim Joo Yeon, Park Ji-Yeon, Klompstra Thomas M, Yoon Ki-Jun, Lim Dae-Sik, Lee Ho-Seok, Kim Jong Kyoung, Choi Eunyoung, Goldenring James R, Cheong Jae-Ho, Kim Hyunki, Stange Daniel E, Lee Heetak, Koo Bon-Kyoung, Lee Ji-Hyun

Abstract excerpt

BACKGROUND: WNT signaling plays a key role in maintaining the gastric epithelium and promoting tumorigenesis. However, how gastric tumors achieve WNT niche independence remains unclear, as mutations on APC or CTNNB1-common mechanisms of ligand-independent WNT activation in colorectal cancer-are infrequent in gastric cancer. Understanding how WNT self-sufficiency is acquired in the stomach is therefore critical....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41398956
DOI: 10.1186/s12943-025-02543-z
PMCID: PMC12766950

Genes

KRAS
SMAD2
WNT7B
APC
CDH1
CP
CTNNB1
RNF43
TP53
WNT2
WNT2B
ZNRF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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