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Single nucleotide variation catalogue from clinical isolates mapped on tertiary and quaternary structures of ESX-1 related proteins reveals critical regions as putative Mtb therapeutic targets

2023-06-23

Abstract excerpt

Proteins encoded by the ESX-1 genes of interests are essential for full virulence in all Mycobacterium tuberculosis complex (MTBc) lineages, the pathogens with the highest mortality worldwide. Identifying critical regions in these ESX-1 related proteins could provide preventive or therapeutic targets for MTB infection, the game changer needed for tuberculosis control. We analysed a compendium of whole genome sequ...

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Literature Corpus work
22ec85ff-87a0-5b95-b3c8-c466d68bffbe
DOI
10.1101/2023.06.22.507254
Open publication

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Single nucleotide variation catalogue from clinical isolates mapped on tertiary and quaternary structures of ESX-1 related proteins reveals critical regions as putative Mtb therapeutic targetsDOI 10.1101/2023.06.22.507254
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