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Article

Comparative genomics of Esx genes from clinical isolates of Mycobacterium tuberculosis provides evidence for gene conversion and epitope variation.

Infection and immunity - 1 Oct 2011

Uplekar Swapna, Heym Beate, Friocourt Véronique, Rougemont Jacques, Cole Stewart T

Abstract excerpt

The 23-membered Esx protein family is involved in the host-pathogen interactions of Mycobacterium tuberculosis. These secreted proteins are among the most immunodominant antigens recognized by the human immune system and have thus been used to develop vaccines and immunodiagnostic tests for tuberculosis (TB). Gene pairs for 10 Esx proteins are contained in the ESX-1 to ESX-5 loci, encoding type VII secretion...

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PMID: 21807910
DOI: 10.1128/IAI.05344-11
PMCID: PMC3187259

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