Article

<i>URA6</i> mutations provide an alternative mechanism for 5-FOA resistance in <i>Saccharomyces cerevisiae</i>

2024-06-04

Abstract excerpt

URA3 is frequently used in the yeast community as the mutation target for 5-fluoroorotic acid (5-FOA) resistance. We identified a novel class of ura6 mutants that can grow in the presence of 5-FOA. Unlike ura3 mutants, ura6 mutants remain prototrophic and grow in the absence of uracil. In addition to 5-FOA resistance, we found that mutations to URA6 also confer resistance to 5-fluorocytosine (5-FC) and 5-fluor...

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Literature Corpus work: 22dd8eaf-3e50-5ba9-a569-c4b4e3e7a272
DOI: 10.1101/2024.06.03.597250

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