Article

Hypermutation in <i>Cryptococcus</i> reveals a novel pathway to 5-fluorocytosine (5FC) resistance

2019-05-13

Abstract excerpt

Drug resistance is a critical challenge in treating infectious disease. For fungal infections, this issue is exacerbated by the limited number of available and effective antifungal agents. Patients infected with the fungal pathogen Cryptococcus are most effectively treated with a combination of amphotericin B and 5-fluorocytosine (5FC). Isolates causing infections frequently develop resistance to 5FC although the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 932ba3a0-3382-5479-9045-e4d95e384b3d
DOI: 10.1101/636928

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypermutation in <i>Cryptococcus</i> reveals a novel pathway to 5-fluorocytosine (5FC) resistanceDOI 10.1101/636928Read

5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus.Semantic proximity Read

Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci.Semantic proximity Read

Genetic mutations in Cryptococcus neoformans pyrimidine salvage pathway enzymes contribute to reduced susceptibility against 5-fluorocytosineSemantic proximity Read

Rapid in vitro evolution of flucytosine resistance in Candida aurisSemantic proximity Read

Mutational Analysis of Flucytosine Resistance in <i>Candida glabrata</i>Semantic proximity Read

Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in <i>Cryptococcus deuterogattii</i>Semantic proximity Read

Transposon mobilization in the human fungal pathogen <i>Cryptococcus deneoformans</i> is mutagenic during infection and promotes drug resistance <i>in vitro</i>Semantic proximity Read

Cross-feeding affects the target of resistance evolution to an antifungal drugSemantic proximity Read

Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattiiSemantic proximity Read

Elevated mutation rates in the multi-azole resistant <i>Aspergillus fumigatus</i> clade drives rapid evolution of antifungal resistanceSemantic proximity Read

tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in <i>Aspergillus fumigatus</i>Semantic proximity Read

Rad53- and Chk1-Dependent DNA Damage Response Pathways Cooperatively Promote Fungal Pathogenesis and Modulate Antifungal Drug SusceptibilitySemantic proximity Read