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Article

Hypomorphic mutations in ura6 confer 5-FOA resistance in fission yeast.

PloS one - 1 Jan 2026

Kowal Constance, Liu Ying, Denis Claire, Arcangioli Benoît, Francesconi Stefania, Gangloff Serge

Abstract excerpt

Genome integrity is essential for cellular survival and adaptation across diverse physiological states. The fission yeast Schizosaccharomyces pombe relies on conserved DNA repair pathways to maintain genome stability during proliferative growth and in the absence of cell division (quiescence/G0). Using 5-fluoroorotic acid (5-FOA) counter-selection, we examined spontaneous mutation accumulation in both conditions...

Topics

Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Mutation
Orotic Acid
Alleles
Drug Resistance, Fungal

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41790722
DOI: 10.1371/journal.pone.0344121
PMCID: PMC12965553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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