Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism.

Current genetics - 1 Sept 1999

Kurtz J E, Exinger F, Erbs P, Jund R

Abstract excerpt

Cytidine metabolism in the yeast Saccharomyces cerevisiae was analyzed by genetic and biochemical approaches. Disruption of a unique ORF (Genbank accession No. U 20865) bearing homology with eucaryotic or bacterial cytidine deaminases abolished cytidine deaminase activity and resulted in 5-fluorocytidine resistance. The gene encoding cytidine deaminase will be referred to as CDD1 (Genbank accession number...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography
Share to Cytidine
Share to Cytidine Deaminase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Deoxycytidine

Share to Drug Resistance

Share to Pyrimidines

Share to Substrate Specificity

Share to Uridine

Source

Identifiers

PMID: 10501935
DOI: 10.1007/s002940050482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism.PMID 10501935Read ↗

Yeast to Study Human Purine Metabolism DiseasesSemantic proximity Read ↗

Saccharomyces Cerevisiae as a Genetic Model in Anticancer Therapy.Semantic proximity Read ↗

[Saccharomyces cerevisiae: an efficient tool and model system for anticancer research].Semantic proximity Read ↗

The distinct biochemical property enables thymidylate kinase as a drug target and participates in pyrimidine drug sensitivity in <i>Candida albicans</i>Semantic proximity Read ↗

dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

Comparative genomic analysis reveals a critical role of de novo nucleotide biosynthesis for Saccharomyces cerevisiae virulence.Semantic proximity Read ↗

Genetic analysis of pyrimidine biosynthetic enzymes in <i>Plasmodium falciparum</i>Semantic proximity Read ↗

A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae.Semantic proximity Read ↗

<i>URA6</i> mutations provide an alternative mechanism for 5-FOA resistance in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

Molecular genetic analysis of Saccharomyces cerevisiae C1-tetrahydrofolate synthase mutants reveals a noncatalytic function of the ADE3 gene product and an additional folate-dependent enzyme.Semantic proximity Read ↗

Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine.Semantic proximity Read ↗

Uncoupling de novo pyrimidine biosynthesis from mitochondrial electron transport by ectopic expression of cytosolic DHODHSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.