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Functional Genomic Analysis of Fluconazole Susceptibility in the Pathogenic Yeast <i>Candida glabrata</i> : Roles of Calcium Signaling and Mitochondria

22 Apr 2004

Abstract excerpt

The pathogenic yeast Candida glabrata exhibits innate resistance to fluconazole, the most commonly used antifungal agent. By screening a library of 9,216 random insertion mutants, we identified a set of 27 genes which upon mutation, confer altered fluconazole susceptibility in C. glabrata. Homologues of three of these genes have been implicated in azole and/or drug resistance in Saccharomyces cerevisiae: two of...

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PMID: 15105111
DOI: 10.1128/aac.48.5.1600-1613.2004

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