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Article

Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus.

Human molecular genetics - 1 Mar 2017

Odhams Christopher A, Cortini Andrea, Chen Lingyan, Roberts Amy L, Viñuela Ana, Buil Alfonso, Small Kerrin S, Dermitzakis Emmanouil T, Morris David L, Vyse Timothy J, Cunninghame Graham Deborah S

Abstract excerpt

Studies attempting to functionally interpret complex-disease susceptibility loci by GWAS and eQTL integration have predominantly employed microarrays to quantify gene-expression. RNA-Seq has the potential to discover a more comprehensive set of eQTLs and illuminate the underlying molecular consequence. We examine the functional outcome of 39 variants associated with Systemic Lupus Erythematosus (SLE) through the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28062664
DOI: 10.1093/hmg/ddw417
PMCID: PMC5409091

Genes

IKZF2
NADSYN1
TCF7
WDFY4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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