Article

The chromatin modulating NSL complex regulates genes and pathways genetically linked to Parkinson’s disease

2023-01-18

Abstract excerpt

Genetic variants conferring risk for Parkinson’s disease have been highlighted through genome-wide association studies, yet exploration of their specific disease mechanisms is lacking. Two Parkinson’s disease candidate genes, KAT8 and KANSL1 , identified through genome-wide studies and a PINK1-mitophagy screen, encode part of the histone acetylating non-specific lethal complex. This complex localises to the nucl...

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Literature Corpus work: 22c936d6-b468-57b7-9f6f-eedb580f6e54
DOI: 10.1101/2023.01.16.523926

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