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Article

Establishing gene regulatory networks from Parkinson's disease risk loci.

Brain : a journal of neurology - 29 Jul 2022

Farrow Sophie L, Schierding William, Gokuladhas Sreemol, Golovina Evgeniia, Fadason Tayaza, Cooper Antony A, O'Sullivan Justin M

Abstract excerpt

The latest meta-analysis of genome-wide association studies identified 90 independent variants across 78 genomic regions associated with Parkinson's disease, yet the mechanisms by which these variants influence the development of the disease remains largely elusive. To establish the functional gene regulatory networks associated with Parkinson's disease risk variants, we utilized an approach combining spatial...

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Identifiers

PMID: 35094046
DOI: 10.1093/brain/awac022
PMCID: PMC9373962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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