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Article

Allele-specific expression of Parkinson's disease susceptibility genes in human brain.

Scientific reports - 12 Jan 2021

Langmyhr Margrete, Henriksen Sandra Pilar, Cappelletti Chiara, van de Berg Wilma D J, Pihlstrøm Lasse, Toft Mathias

Abstract excerpt

Genome-wide association studies have identified genetic variation in genomic loci associated with susceptibility to Parkinson's disease (PD), the most common neurodegenerative movement disorder worldwide. We used allelic expression profiling of genes located within PD-associated loci to identify cis-regulatory variation affecting gene expression. DNA and RNA were extracted from post-mortem superior frontal gyrus...

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Identifiers

PMID: 33436766
DOI: 10.1038/s41598-020-79990-9
PMCID: PMC7804400

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