Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The non-specific lethal complex regulates genes and pathways genetically linked to Parkinson’s disease

31 Jul 2023

Abstract excerpt

Genetic variants conferring risks for Parkinson's disease have been highlighted through genome-wide association studies, yet exploration of their specific disease mechanisms is lacking. Two Parkinson's disease candidate genes, KAT8 and KANSL1, identified through genome-wide studies and a PINK1-mitophagy screen, encode part of the histone acetylating non-specific lethal complex. This complex localizes to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37522749
DOI: 10.1093/brain/awad246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The non-specific lethal complex regulates genes and pathways genetically linked to Parkinson’s diseasePMID 37522749Read ↗

The chromatin modulating NSL complex regulates genes and pathways genetically linked to Parkinson’s diseaseSemantic proximity Read ↗

Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease.Semantic proximity Read ↗

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 lociSemantic proximity Read ↗

Large-scale pathway-specific polygenic risk, transcriptomic community networks and functional inferences in Parkinson diseaseSemantic proximity Read ↗

17q21.31 locus regulates Parkinson’s disease relevant pathways through <i>KANSL1</i> activitySemantic proximity Read ↗

Establishing gene regulatory networks from Parkinson's disease risk loci.Semantic proximity Read ↗

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at Chr16q11.2 and on the MAPT H1 alleleSemantic proximity Read ↗

Transcriptional pathways of definitive ALS genes implicate novel disease-associated target genesSemantic proximity Read ↗

Prognostic and biological roles of Parkinson’s disease genes in cancerSemantic proximity Read ↗

Genetic networks in Parkinson’s and Alzheimer’s diseaseSemantic proximity Read ↗

Brain Proteome-Wide and Transcriptome-Wide Asso-ciation Studies, Bayesian Colocalization, and Mendelian Randomization Analyses Reveal Causal Genes of Parkinson's Disease.Semantic proximity Read ↗

Genome-wide Identification of the Genetic Basis of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.