Article

17q21.31 locus regulates Parkinson’s disease relevant pathways through <i>KANSL1</i> activity

2025-03-17

Abstract excerpt

An inversion polymorphism at the 17q21.31 locus defines the H1 and H2 haplotypes, with the former linked to multiple neurodegenerative disorders, including an increased risk of Parkinson’s disease (PD). Although the high linkage disequilibrium at this locus has made it difficult to decipher which gene(s) drive the PD association, there is increasing evidence to support the role of KANSL1 as a risk gene. KANSL1 ha...

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Literature Corpus work: 8c24b728-53e8-54b1-9eac-22435ceee063
DOI: 10.1101/2025.03.17.641409

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