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Article

Nuclear dengue virus NS5 antagonizes expression of PAF1-dependent immune response genes.

PLoS pathogens - 1 Nov 2021

Petit Marine J, Kenaston Matthew W, Pham Oanh H, Nagainis Ariana A, Fishburn Adam T, Shah Priya S

Abstract excerpt

Dengue virus (DENV) disruption of the innate immune response is critical to establish infection. DENV non-structural protein 5 (NS5) plays a central role in this disruption, such as antagonism of STAT2. We recently found that DENV serotype 2 (DENV2) NS5 interacts with Polymerase associated factor 1 complex (PAF1C). The primary members of PAF1C are PAF1, LEO1, CTR9, and CDC73. This nuclear complex is an emerging...

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Identifiers

PMID: 34797876
DOI: 10.1371/journal.ppat.1010100
PMCID: PMC8641875

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