Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq

6 Oct 2023

Abstract excerpt

Genomic and proteomic screens have identified numerous host factors of SARS-CoV-2, but efficient delineation of their molecular roles during infection remains a challenge. Here we use Perturb-seq, combining genetic perturbations with a single-cell readout, to investigate how inactivation of host factors changes the course of SARS-CoV-2 infection and the host response in human lung epithelial cells. Our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to SARS-CoV-2 and COVID-19 Research
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37803001
DOI: 10.1038/s41467-023-41788-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seqPMID 37803001Read ↗

Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seqSemantic proximity Read ↗

Global siRNA Screen Reveals Critical Human Host Factors of SARS-CoV-2 Multicycle ReplicationSemantic proximity Read ↗

Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infectionSemantic proximity Read ↗

Identification and Targeting of Regulators of SARS-CoV-2-Host Interactions in the Airway EpitheliumSemantic proximity Read ↗

Defining the host dependencies and the transcriptional landscape of RSV infection and bystander activationSemantic proximity Read ↗

Integrated multi-omics analyses identify key anti-viral host factors and pathways controlling SARS-CoV-2 infectionSemantic proximity Read ↗

Systematic Genome-Scale Identification of Host Factors for SARS-CoV-2 Infection Across Models Yields a Core Single Gene Dependency; <i>Ace2</i>Semantic proximity Read ↗

Profiling transcription factor sub-networks in type I interferon signaling and in response to SARS-CoV-2 infectionSemantic proximity Read ↗

Functional Landscape of SARS-CoV-2 Cellular RestrictionSemantic proximity Read ↗

SARS-CoV-2 Nsp2 reprograms host immunity to drive pathogenic inflammationSemantic proximity Read ↗

Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signalingSemantic proximity Read ↗

Resolving <i>in vitro</i> heterogeneity of host functional responses to HCoV-229E via single-cell analysesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.