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Article

A whole genome screen for HIV restriction factors

14 Nov 2011

Abstract excerpt

BACKGROUND: Upon cellular entry retroviruses must avoid innate restriction factors produced by the host cell. For human immunodeficiency virus (HIV) human restriction factors, APOBEC3 (apolipoprotein-B-mRNA-editing-enzyme), p21 and tetherin are well characterised. RESULTS: To identify intrinsic resistance factors to HIV-1 replication we screened 19,121 human genes and identified 114 factors with significant...

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PMID: 22082156
DOI: 10.1186/1742-4690-8-94

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