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Article

Impact of Polygenic Interactions With Anticholinergic Burden on Cognition and Brain Structure in Psychosis Spectrum Disorders.

The American journal of psychiatry - 1 Aug 2025

Zhang Lusi, Ivleva Elena I, Parker David A, Hill Scot K, Lizano Paulo L, Keefe Richard S E, Keedy Sarah K, McDowell Jennifer E, Pearlson Godfrey D, Clementz Brett A, Keshavan Matcheri S, Gershon Elliot S, Tamminga Carol A, Sweeney John A, Bishop Jeffrey R

Abstract excerpt

OBJECTIVE: The authors sought to determine whether genetic predispositions to cognitive ability or psychiatric conditions interact with anticholinergic burden (AChB) to impact cognition and brain structure in individuals with psychotic disorders. METHODS: Participants with psychosis spectrum disorders (N=1,704) from the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) consortium, 18-65 years of...

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PMID: 40432343
DOI: 10.1176/appi.ajp.20240709

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