Article

ALOHA: Aggregated local extrema splines for high-throughput dose-response analysis

2021-03-31

Abstract excerpt

Computational methods for genomic dose-response integrate dose-response modeling with bioinformatics tools to evaluate changes in molecular and cellular functions related to pathogenic processes. These methods use parametric models to describe each gene’s dose-response, but such models may not adequately capture expression changes. Additionally, current approaches do not consider gene co-expression networks. When...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2296f45f-88b0-5d16-a285-9173665a05a0
DOI: 10.1101/2021.03.29.437588

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ALOHA: Aggregated local extrema splines for high-throughput dose-response analysisDOI 10.1101/2021.03.29.437588Read

Transcriptional benchmark dose modeling: Exploring how advances in chemical risk assessment may be applied to the radiation fieldSemantic proximity Read

Gene expression, dose-response, and phenotypic anchoring: applications for toxicogenomics in risk assessment.Semantic proximity Read

Predicting drug combination response surfacesSemantic proximity Read

High throughput data-based, toxicity pathway-oriented development of a quantitative adverse outcome pathway network linking AHR activation to lung damagesSemantic proximity Read

A statistical framework for assessing pharmacological response and biomarkers using uncertainty estimatesSemantic proximity Read

From Toxicogenomics Data to Cumulative Assessment Groups: A Mechanistic Framework for Chemical GroupingSemantic proximity Read

Gene set enrichment analysis for non-monotone association and multiple experimental categories.Semantic proximity Read

Concordance of transcriptional and apical benchmark dose levels for conazole-induced liver effects in mice.Semantic proximity Read

Molecular circuits, biological switches, and nonlinear dose-response relationships.Semantic proximity Read

Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure.Semantic proximity Read

Non-parametric synergy modeling with Gaussian processesSemantic proximity Read

Systematic comparison of temporal transcriptional responses to hepatotoxicants in primary human hepatocytes and HepaRG cells using concentration-response modelling of gene co-expression networksSemantic proximity Read