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Article

Concordance of transcriptional and apical benchmark dose levels for conazole-induced liver effects in mice.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2013

Bhat Virunya S, Hester Susan D, Nesnow Stephen, Eastmond David A

Abstract excerpt

The ability to anchor chemical class-based gene expression changes to phenotypic lesions and to describe these changes as a function of dose and time informs mode-of-action determinations and improves quantitative risk assessments. Previous global expression profiling identified a 330-probe cluster differentially expressed and commonly responsive to 3 hepatotumorigenic conazoles (cyproconazole, epoxiconazole, and...

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PMID: 23970803
DOI: 10.1093/toxsci/kft182

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