Article

From Toxicogenomics Data to Cumulative Assessment Groups: A Mechanistic Framework for Chemical Grouping

2025-01-26

Abstract excerpt

The grouping of chemicals based on shared properties or molecular mechanisms of action is pivotal for advancing regulatory toxicology, reducing data gaps, and enabling cumulative risk assessments. This study introduces a novel framework usingChemical-Gene-Phenotype-Disease (CGPD) tetramers derived from the Comparative Toxicogenomics Database (CTDbase). Our approach integrates toxicogenomics data to identify and cl...

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Literature Corpus work: c42f449b-0b05-5d5c-a303-e671047911ee
DOI: 10.1101/2025.01.24.634648

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