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Article

Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure.

Reproductive toxicology (Elmsford, N.Y.) - 1 Jul 2016

Zhang Guozhu, Marvel Skylar, Truong Lisa, Tanguay Robert L, Reif David M

Abstract excerpt

Robust computational approaches are needed to characterize systems-level responses to chemical perturbations in environmental and clinical toxicology applications. Appropriate characterization of response presents a methodological challenge when dealing with diverse phenotypic endpoints measured using in vivo systems. In this article, we propose an information-theoretic method named Aggregate Entropy (AggE) and...

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Identifiers

PMID: 27132190
DOI: 10.1016/j.reprotox.2016.04.012
PMCID: PMC4905797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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